Predict, prevent and manage moral injuries in Canadian frontline healthcare workers and leaders facing the COVID-19 pandemic: Protocol of a mixed methods studyResearch article Published on 2022-12-012022-10-05 Journal: SSM - Mental Health [Category] 바이오마커, [키워드] addition adjusted analysis Biomarker Biomarkers blood sample build collected condition contribute COVID-19 COVID-19 crisis COVID-19 pandemic develop disease emotional event expand frontline healthcare worker generate group Health healthcare healthcare worker Healthcare workers identify Inflammation Injury knowledge mental health Moral Moral injuries observé occur Occurrence participant predict predictor Prevent protocol psychosocial stressor Psychosocial stressors at work Quantitative Quantitative data questionnaire recommendation reduce Research risk Risk factors severity Stress Stressor [DOI] 10.1016/j.ssmmh.2022.100124 [Article Type] Research article
Effects of boosted mRNA and adenoviral-vectored vaccines on immune responses to omicron BA.1 and BA.2 following the heterologous CoronaVac/AZD1222 vaccinationArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome addition adenoviral-vectored vaccine antibody AZD1222 binding antibody BNT162b2 booster booster vaccination Booster vaccine comparable Complete coronavirus Coronavirus 2019 COVID-19 demonstrated develop dose Effect enrolled enzyme-linked immunosorbent Heterologous highest immune evasion immune response Immunogenicity analysis individual induce interferon-γ Messenger RNA Mild moderate mRNA mRNA vaccine mRNA-1273 mutations NAb titer NAbs neutralization neutralize Neutralizing Neutralizing activity neutralizing antibody observé Omicron variant Omicron. overcome participant raise receive receiving reduction response Serious Adverse Events significant increase Spike protein T-cell activation T-cell Response T-cell responses vaccination Vaccine waning immunity was recorded were measured [DOI] 10.1002/jmv.28044 PMC 바로가기
A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two dosesArticle Published on 2022-10-252022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Administering boost caused coronavirus COVID-19 CP: Immunology Donor dose elicit elicited extended interval humoral Humoral response humoral responses individual Infection long interval mRNA vaccine observé omicron regimen robust SARS-CoV-2 SARS-CoV-2 BNT162b2 second dose significantly spike glycoproteins third mRNA vaccine dose vaccinated individuals variant variants of concern variants of concern. VoC VOCs [DOI] 10.1016/j.celrep.2022.111554 PMC 바로가기
Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19Article Published on 2022-10-122022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] 28-day mortality adjusted odds ratio association clinical clinical condition clinical phenotype Critically ill Delta dose Factors France French humoral Immunocompromised Immunocompromised patient Infection information intensive care intensive care unit less mortality rate multicenter observé Occurrence omicron outcome Patient patients patients with COVID-19 phenotype prospective cohort study response to vaccination SARS-CoV-2 variant severe COVID-19 severe disease severity significantly higher Vaccine variant viral genome [DOI] 10.1038/s41467-022-33801-z PMC 바로가기
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotypeArticle Published on 2022-10-072022-11-16 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] animal model bronchial epithelial cell cell culture system clone clones cultures Delta epithelial ferret hamsters immune evasion immunized in vitro in vivo Infection K18-hACE2 mice less mice mutant naïve nasal observé pathogenicity phenotype reduced replication Replication spike gene Surveillance the SARS-CoV-2 VoC [DOI] 10.1038/s41467-022-33632-y PMC 바로가기
Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort studyArticle Published on 2022-10-022022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 진단, [키워드] antibody antibody waning attenuate BNT162b2 both group ChAdOx1-S chronic condition clinical factor cohort study Community condition COVID-19 vaccination dose England enrolled evaluate group groups Immunity Immunosuppression individual observé prospective cohort study PROTECT Protective antibody recipient reduced response responses significantly the antibody response therapy vaccination [DOI] 10.1038/s41467-022-33550-z PMC 바로가기
A systematic review and meta-analysis of the IgA seroprevalence in COVID-19 patients: Is there a role for IgA in COVID-19 diagnosis or severity?COVID-19 환자의 IgA 혈청 유병률에 대한 체계적인 검토 및 메타 분석: COVID-19 진단 또는 중증도에서 IgA의 역할이 있습니까?Meta-Analysis Published on 2022-10-012022-09-11 Journal: Microbiological research [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] Abstract acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody association asymptomatic patients Biomarker caused coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 disease determine diagnostic diagnostic test diagnostic tests disease Efficacy Health health problems Humoral response humoral responses IgA Immunity in some include Infection manuscript Meta-analysis Mild observé Patient problems produced Research respiratory SARS-CoV-2 SARS-CoV-2 PCR Seroprevalence severe acute respiratory syndrome Coronavirus Severe patient severe patients severity Susceptibility. symptomatic systematic review Vaccines [DOI] 10.1016/j.micres.2022.127105 PMC 바로가기 [Article Type] Meta-Analysis
SARS-Cov-2 Infection in Severe Asthma Patients Treated With BiologicsArticle Published on 2022-10-012022-11-15 Journal: The journal of allergy and clinical immunology. In [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome administration Admission adverse outcome asked Asthma benralizumab biologic biologics characterized Cohort coronavirus coronavirus disease COVID-19 COVID-19 pandemic Deterioration died disease severity Exacerbation female General population Greece hospital infected patients Infection initial mechanical ventilation mepolizumab observé omalizumab outcome pandemic Patient patients treated physician polymerase chain provided required risk SARS-CoV-2 SARS-COV-2 infection Severe asthma. severe COVID-19 severity systemic corticosteroids therapy treated Treatment was performed [DOI] 10.1016/j.jaip.2022.05.041 PMC 바로가기
Rapid comparative evaluation of SARS-CoV-2 rapid point-of-care antigen testsArticle Published on 2022-10-012022-11-15 Journal: Infection [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] AgPOCT AgPOCTs analytical sensitivity Antigen approach Comparison of antigen-detecting rapid diagnostic tests COVID-19 develop diagnostic diagnostics FIVE Head-to-head comparison highest identify medium methodology negative control Non-functional Non-functional AgPOC tests observé offered point-of-care point-of-care test positive result provide Rapid recognize Saliva SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 genome SARS-CoV-2 viral load sensitivity Support Test Test sensitivity. tested Viral load were used [DOI] 10.1007/s15010-022-01810-1 PMC 바로가기
Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in IcelandArticle Published on 2022-09-282022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] antibody binding BNT162b2 booster booster vaccination Combination Delta delta variant Effect greater Iceland infections inhibitory activity initiated majority mRNA mRNA vaccine mRNA-1273 observé omicron qPCR test reflected risk risk of infection SARS-CoV-2 infections SARS-CoV-2 variant Spread vaccination vaccination against COVID-19 vaccination schedule Vaccine virus [DOI] 10.1038/s41467-022-33076-4 PMC 바로가기